Aspley Guise station is managed by West Midlands Trains (London Northwestern Railway) and is located in Central Bedfordshire within the East of England area of England.

Figures for 2023-24 show that 1,044 journeys were made between Aspley Guise and Bletchley—that's 31% of all passenger journeys at this station! Previously the most common journey flow was to & from Bedford.

Passenger numbers for Aspley Guise peaked during 1997-98 with 21,944 estimated passengers.